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Preclinical Toxicology Studies
Perry Scientific’s state-of-the-art facility specializes in contract
performance of toxicology studies. Non-GLP toxicology studies are intended
to provide preliminary assessment of a drug’s safety. GLP toxicology
studies are required as a prerequisite for filing an IND package, prior
to Phase I clinical trials.
Non-GLP toxicology studies can be performed on research grade materials
to reduce costs and promote study design flexibility. These early stage
studies can be performed prior to committing to the substantial costs
in time and
financial resources required to producing GMP grade material.
GLP toxicology studies are required as part of the IND package and are normally
performed only on GMP produced material. GLP-compliant regulatory tests are
mandated for marketing approval.
Toxicology Study Types
- LD-50
- Maximum tolerated dose (MTD)
- Acute Toxicity
- Subchronic Toxicity
- Chronic Toxicity
- Single dose range-finding and acute toxicity
studies
- Repeated Dose
- Sensitization
- Irritation
- BCGM Assays
- carcinogenicity studies
Routes of Administration
All
standard routes of administration are offered. Our strength is accommodating
specialized client needs for treatment regimens.
- Subcutaneous
- Intraperitoneal
- Intravenous
- Intramuscular
- Topical
- Oral
- Controlled release pumps
Species
Perry Scientific offers all standard test species. The following species
can be housed at Perry Scientific's AAALAC-accredited vivarium.
- Mouse
- Rat
- Hamster
- Guinea Pig
- Rabbit
- Dog
- Sheep
- Pig (Mini, Micro, Domestic)
Ancillary Services
Perry Scientific’s study services offered extend beyond the in-life
phase of preclinical testing. The following ancillary, yet integral, services
are offered:
- Clinical Pathology
- Gross Pathology
- Histopathology
- Parasitology
- Microbiology
- Toxicokinetics
- Data Analysis
- Report Writing
- Dermatology
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