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Preclinical Diabetes Studies
Perry Scientific is one of the most experienced CROs in preclinical
diabetes research. We offer a number of different diabetes models
for testing both new drugs and new formulations of insulin. We
offer models in mice, rats and canines.
Diabetes is a chronic disease in which the body does not produce or
properly use insulin. It is estimated that there are 20.8 million
adults and children in the United States, or 7% of the population, who
have diabetes. While an estimated 14.6 million have been diagnosed
with diabetes, 6.2 million people (or nearly one-third) are unaware that
they have the disease. Worldwide the disease afflicts nearly 194
million people and this figure is expected to increase to almost 333
million by the year 2025.
The American National Institute of Health 2002 survey estimated direct
and indirect medical expenditures attributable to diabetes in the United
States at $132 billion.
Preclinical Diabetes Models
Offered by Perry Scientific
Mouse Diabetes Models
- NOD mice: Non-obese diabetic (NOD) mice spontaneously
develop insulin-dependent (type 1) diabetes mellitus (IDDM) caused by
T cell destruction of the insulin-producing islet beta-cells.
- ob mice: These mice harbor mutations in the obese
(ob) gene. For example, the BTBR mouse strain harbors alleles promoting
insulin resistance. When made genetically obese (ob/ob), these
mice develop severe type 2 diabetes with a fasting glucose of 400 mg/dL.
- db mice: The genetically diabetic db/db mouse
exhibits symptoms that resemble human type 2 diabetes mellitus, including
related factors such as delayed wound healing.
- DIO mice: The Diet-Induced Obese (DIO) mouse
model is a C57BL / 6J mouse fed a 60% high fat diet for 12 weeks.
Rat Diabetes Models
- Zucker diabetic fatty rats (fa/fa): This is a very common and
well defined rat model. The Zucker rat is used as a model for
non-insulin-dependent type 2 diabetes as well as obesity.
Canine Diabetes Models
- STZ Canine
model: The STZ canine diabetes models is very hard to produce
and maintain and Perry Scientific is one of the few CROs with
enough experience to make it reproducible. We induce diabetes
using streptozotocin (STZ). With the correct administration
of STZ, the pancreatic islets can be reduced in volume and number
resulting in 90% to 100% pancreatectomy.
- Canine surgical pancreatectomy model: This model uses surgical intervention
to completely remove the pancreas. It is much more invasive
than the STZ model and recovery time for the animals is longer.
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